Department of Vascular Surgery, University of Balamand, Beirut, Lebanon
Clin Appl Thromb Hemost. 2015 Jan;21(1):87-90. doi: 10.1177/1076029613497423. Epub 2013 Jul 26.
Postthrombotic syndrome (PTS) is a common complication of deep vein thrombosis. This study aims to assess the role of recurrent venous thrombosis and inherited thrombophilia in the pathogenesis of PTS. A series of 206 patients diagnosed with lower extremity venous thrombosis were retrospectively reviewed. The PTS was observed in 30.58% of the patients. Recurrent venous thrombosis was identified in 3.4% of the patients without PTS and in 33.3% of patients with PTS (P < .001). Inherited thrombophilia alone or in association with recurrent venous thrombosis was more commonly detected when PTS was moderate to severe (P = .04 and <.001) or severe (P < .001). Recurrent venous thrombosis increases the incidence of PTS significantly. The severity of PTS raises when an underlying thrombophilia is present either alone or in association with recurrent venous thrombosis.
血栓后综合征（PTS）是深静脉血栓形成的常见并发症。本研究旨在评估复发性静脉血栓形成和遗传性血栓形成倾向在 PTS 发病机制中的作用。回顾性分析了 206 例下肢静脉血栓形成患者。30.58%的患者出现 PTS。无 PTS 的患者中复发性静脉血栓形成发生率为 3.4%，而 PTS 患者为 33.3%（P <.001）。当 PTS 为中度至重度（P =.04 和 <.001）或重度（P <.001）时，单独或与复发性静脉血栓形成相关的遗传性血栓形成倾向更常见。复发性静脉血栓形成显著增加 PTS 的发生率。当存在潜在的血栓形成倾向时，无论是单独存在还是与复发性静脉血栓形成相关，PTS 的严重程度都会升高。
