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[面部和颈部蜂窝织炎患者中分子水平在评估内毒素血症严重程度中的诊断重要性]

[The diagnostic importance of the level of middle molecules in assessing the severity of endotoxemia in patients with phlegmons of the face and neck].

作者信息

Zakharov Iu S

出版信息

Stomatologiia (Mosk). 1990 May-Jun;69(3):43-4.

PMID:2389273
Abstract

Blood medium-mass molecules (MMM) concentrations were measured in 68 patients with phlegmons of the face and neck, aged 24 to 65. The patients were divided into 3 groups with variously manifesting symptoms of endogenous intoxication. MMM concentration was found to be increasing with the growth of intoxication of the body; their highest concentration was detected in vast putrefactive necrotic phlegmons induced by anaerobic infection and accompanied by dysfunction of a number of vital organs responsible for gas exchange, detoxication, hemodynamics, excretion, etc. Regular changes in MMM levels were revealed, reflecting the condition severity, pattern, and manifestation of endogenous intoxication. Blood MMM levels may be regarded as an objective characteristic of endotoxemia severity in patients with phlegmons of the face and neck.

摘要

对68名年龄在24至65岁之间的面部和颈部蜂窝织炎患者的血液中、等分子量分子(MMM)浓度进行了测量。这些患者被分为3组,其体内中毒症状表现各异。发现MMM浓度随着身体中毒程度的加重而升高;在由厌氧菌感染引起的广泛腐败坏死性蜂窝织炎中检测到其最高浓度,且伴有负责气体交换、解毒、血液动力学、排泄等多个重要器官的功能障碍。揭示了MMM水平的规律性变化,反映了内源性中毒的病情严重程度、类型和表现。血液MMM水平可被视为面部和颈部蜂窝织炎患者内毒素血症严重程度的客观特征。

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