Khedr Yahya A H, Khedr Abdulla H
Faculty of Medicine, Ophthalmology, Ain Shams University, Cairo, Egypt.
BMJ Case Rep. 2013 Jul 26;2013:bcr2013200391. doi: 10.1136/bcr-2013-200391.
Ocular diseases are very common in many of the systemic diseases such as sarcoidosis, and may sometimes be the presenting symptom of the disease. In this case report, we present an unusual reaction of the sarcoid granuloma to carbonic anhydrase enzyme inhibitors (CAIs), which was encountered in a patient with ocular sarcoidosis. This observation was taken after a 2-week interval between a CT scan orbits and an MRI orbits which showed a decrease in size from 4×3×4 cm to 2.5×2.5×2 cm, respectively. We suspected the dorzolamide CAI to have had a significant role in the reduction in size. It is suggested that acidotic changes that occur due to the effect of the carbonic anhydrase inhibitor causes electrolyte imbalance, intracellular as well as extracellular, which lead to the reduction in the size of the granuloma.
眼部疾病在许多全身性疾病（如结节病）中非常常见，有时可能是该疾病的首发症状。在本病例报告中，我们呈现了结节病肉芽肿对碳酸酐酶抑制剂（CAIs）的一种不寻常反应，此反应出现在一名眼部结节病患者身上。这一观察结果是在眼眶CT扫描和眼眶MRI扫描间隔2周后得出的，扫描结果显示肿物大小分别从4×3×4厘米减小至2.5×2.5×2厘米。我们怀疑多佐胺CAI在肿物缩小过程中起到了重要作用。有人提出，碳酸酐酶抑制剂的作用导致的酸中毒变化会引起细胞内和细胞外的电解质失衡，进而导致肉芽肿体积减小。
