Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
J Bone Miner Res. 2014 Feb;29(2):389-91. doi: 10.1002/jbmr.2054.
There is a wide range of practices regarding times between bone density (BMD) measurements in osteopenic women. If decisions to treat osteoporosis are to be based on absolute fracture risk, then projections of fracture risk are a logical basis for determining appropriate intervals for BMD testing. Fracture risk depends mainly on age and BMD, and bone loss in older women is relatively constant at ∼1% annually, so it is possible to project fracture risk into the future and estimate when an individual's risk will approach the threshold for intervention. Modeling scenarios for a range of osteopenic baseline BMDs in 65-year-old women shows a remarkable consistency in the doubling time for Fracture Risk Assessment Tool (FRAX)-assessed fracture risk: 5 to 6 years. This estimate is of immediate relevance to clinical practice in that it can be used to determine how long to wait before reassessing BMD and fracture risk in women whose other risk factors are stable.
在骨质疏松症女性中，骨密度（BMD）测量的时间间隔存在广泛的实践差异。如果要基于绝对骨折风险来做出骨质疏松症治疗决策，那么骨折风险预测就是确定 BMD 检测合适间隔的合理基础。骨折风险主要取决于年龄和 BMD，而老年女性的骨质流失相对稳定，每年约为 1%，因此可以对未来的骨折风险进行预测，并估计个体的风险何时会接近干预阈值。对 65 岁女性一系列骨质疏松症基线 BMD 的建模场景表明，骨折风险评估工具（FRAX）评估的骨折风险翻倍时间具有显著的一致性：5 至 6 年。这一估计与临床实践直接相关，因为它可以用于确定在其他危险因素稳定的女性中，需要等待多长时间才能重新评估 BMD 和骨折风险。
