Kiprov Dobri D
Division of Immunotherapy, California Pacific Medical Center, San Francisco, California; Apheresis Care Group and Fresenius Medical Care, San Francisco, California.
J Clin Apher. 2013 Dec;28(6):387-9. doi: 10.1002/jca.21286. Epub 2013 Jul 27.
The population of baby boomers (age 60-65) is rapidly increasing globally. The aging of the human body is associated with the decline of cellular function which leads to the development of a variety of diseases. The increased demand for health care for the aging population creates significant financial burden to any healthcare system. Developing strategies and health intervention methods to ameliorate this situation is paramount. Experiments utilizing heterochronic parabiosis in mice have demonstrated that replacing the aging cellular milieu with the plasma of a young experimental animal leads to reversal of cellular senescence. This article describes a hypothetical model of intermittent heterochronic plasma exchange in humans as a modality for heterochronic parabiosis in an attempt to delay cellular senescence.
全球范围内，婴儿潮一代（60 - 65岁）的人口正在迅速增长。人体衰老与细胞功能衰退相关，而细胞功能衰退会导致多种疾病的发生。老年人口对医疗保健需求的增加给任何医疗系统都带来了巨大的经济负担。制定改善这种状况的策略和健康干预方法至关重要。利用小鼠异种共生实验表明，用年轻实验动物的血浆替代衰老的细胞环境可导致细胞衰老的逆转。本文描述了一种人类间歇性异种血浆交换的假设模型，作为异种共生的一种方式，试图延缓细胞衰老。
