多种水介导相互作用的策略性靶向：一种简洁且合理的基于结构的强效和选择性基质金属蛋白酶-13抑制剂设计方法。 - Suppr

Strategic targeting of multiple water-mediated interactions: a concise and rational structure-based design approach to potent and selective MMP-13 inhibitors.

作者信息

Fischer Thomas, Riedl Rainer

机构信息

Institute for Chemistry and Biological Chemistry, Zurich University of Applied Sciences-ZHAW, Einsiedlerstrasse 31, 8820 Wädenswil, Switzerland.

出版信息

ChemMedChem. 2013 Sep;8(9):1457-61, 1572. doi: 10.1002/cmdc.201300278. Epub 2013 Jul 26.

DOI:10.1002/cmdc.201300278

PMID:23894097

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4281860/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4080/4281860/e254a11d02b5/cmdc-8-1457-g1.jpg

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Strategic targeting of multiple water-mediated interactions: a concise and rational structure-based design approach to potent and selective MMP-13 inhibitors.

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