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[吡喹酮制备与应用的研究进展]

[Progress of research on preparation and application of praziquantel].

作者信息

Wu De-Zhi, Ma Zheng, Liu Yun-Feng, Zhu Wei-Feng, Ning An

机构信息

Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.

出版信息

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2013 Apr;25(2):194-6.

Abstract

Praziquantel remains the drug of choice for schistosomiasis, but it has the low bioavailability and single dosage form. This paper reviews the properties of praziquantel in vivo and in vitro, the pathogenic characteristics of schistosomiasis, and the progress of research on the formation of praziquantel, so as to enhance the efficiency of praziquantel against schistosomiasis and provide consults for relevant drug researches.

摘要

吡喹酮仍然是治疗血吸虫病的首选药物,但它生物利用度低且剂型单一。本文综述了吡喹酮的体内外特性、血吸虫病的致病特征以及吡喹酮制剂研究进展,以提高吡喹酮治疗血吸虫病的疗效,并为相关药物研究提供参考。

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