Department of Biomolecular Science, University of Science and Technology, 113 Gwahangno, Yuseong-gu, Daejeon 305-333, Republic of Korea.
Curr Top Med Chem. 2013 Aug;13(16):2026-33. doi: 10.2174/15680266113139990127.
Antimicrobial peptides are a group of natural or semi-synthetic molecules possessing antimicrobial activities against bacteria, fungi, viruses, parasites, etc. They are considered as promising candidates for treatment of microbial infections and suppression of microbial resistance. The increasing emergence of bacterial resistance has required development of new efficient antibiotics that can be added to the antibacterial armamentarium. The marine world provides a rich source of antimicrobial peptides. That world has not been highly explored yet, and much more effort is required in order to discover new efficient antimicrobial peptides. In the present article, we have reviewed the recent progress in the field of marine antimicrobial peptides from 2009 until the mid of 2012.
抗菌肽是一组具有抗细菌、真菌、病毒、寄生虫等活性的天然或半合成分子。它们被认为是治疗微生物感染和抑制微生物耐药性的有前途的候选药物。细菌耐药性的不断出现要求开发新的有效抗生素,以增加抗菌武器库。海洋世界提供了丰富的抗菌肽来源。这个世界还没有得到充分的探索,为了发现新的有效抗菌肽,还需要付出更多的努力。在本文中,我们回顾了 2009 年至 2012 年年中期间海洋抗菌肽领域的最新进展。