Zhao Qi, Weber Erin, Yang Haitao
Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA.
Infect Disord Drug Targets. 2013 Apr;13(2):116-27. doi: 10.2174/18715265113139990024.
The recent, fatal outbreak of the novel coronavirus strain in the Middle East highlights the real threat posed by this unique virus family. Neither pharmaceutical cures nor preventive vaccines are clinically available to fight against coronavirus associated syndromes, not to mention a lack of symptom soothing drugs. Development of treatment options is complicated by the unpredictable, recurring instances of cross-species viral transmission. The vastly distributing virus reservoir and the rapid rate of host-species exchange of coronavirus demands wide spectrum potency in an ideal therapeutic. Through summarizing the available information and progress in coronavirus research, this review provides a systematic assessment of the potential wide-spectrum features on the most popular drug targets including viral proteases, spike protein, RNA polymerases and editing enzymes as well as host-virus interaction pathways associated with coronaviruses.
近期在中东爆发的新型冠状病毒致死疫情凸显了这一独特病毒家族所构成的真实威胁。目前临床上既没有治疗药物，也没有预防性疫苗可用于对抗冠状病毒相关综合征，更不用说缺乏缓解症状的药物了。跨物种病毒传播的不可预测性和反复出现的情况使治疗方案的开发变得复杂。冠状病毒广泛分布的病毒库以及宿主物种间快速的交换速度要求理想的治疗药物具有广谱效力。通过总结冠状病毒研究的现有信息和进展，本综述对最常见药物靶点（包括病毒蛋白酶、刺突蛋白、RNA聚合酶和编辑酶）以及与冠状病毒相关的宿主-病毒相互作用途径的潜在广谱特性进行了系统评估。
