在纽卡斯尔千家庭出生队列研究中，儿童期感染而非早期生长发育，对14岁儿童的听力有影响。

Childhood infections, but not early life growth, influence hearing in the Newcastle thousand families birth cohort at age 14 years.

作者信息

Pearson Fiona, Mann Kay D, Nedellec Raphael, Rees Adrian, Pearce Mark S

机构信息

Institute of Health & Society, Newcastle University, Newcastle upon Tyne, UK.

Institute of Health & Society, Newcastle University, Newcastle upon Tyne, UK ; Ecole Nationale de la Statistique et de l'Analyse de l'Information, Rennes, France.

出版信息

BMC Ear Nose Throat Disord. 2013 Jul 29;13:9. doi: 10.1186/1472-6815-13-9. eCollection 2013.

DOI:10.1186/1472-6815-13-9

PMID:23895514

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3735408/

Abstract

BACKGROUND

While current research priorities include investigations of age-related hearing loss, there are concerns regarding effects on childhood hearing, for example through increased personal headphone use. By utilising historical data, it is possible to assess what factors may have increased hearing problems in children in the past, and this may be used to inform current public health policies to protect children against hearing loss and in turn reduce the long-term burden on individuals and services that may possible evolve. The aim of this study was to investigate which factors in early life significantly impacted on hearing level in childhood using existing data from the Newcastle Thousand Families Study, a 1947 birth cohort.

METHODS

Data on early life factors, including growth, socio-economic status and illness, and hearing at age 14 years were collated for a representative subset of individuals from the cohort (n = 147). Factors were assessed using linear regression analysis to identify associations with hearing thresholds.

RESULTS

Males were found to have lower hearing thresholds at 250 Hz, 500 Hz and 1 kHz. Main analyses showed no associations between hearing thresholds and early life growth or socio-economic indicators. An increasing number of ear infections from birth to age 13 years was associated with hearing thresholds at 250Hz (p = 0.04) and 500Hz (p = 0.03), which remained true for females (p = 0.050), but not males (p = 0.213) in sex-specific analysis. Scarlet fever and bronchitis were associated with hearing thresholds at 8 kHz. After adjustment for all significant predictors at each frequency, results remained unchanged.

CONCLUSIONS

We found no associations between childhood hearing thresholds and early life growth and socio-economic status. Consistent with other studies, we found associations between childhood infections and hearing thresholds. Current public health strategies aimed at reducing childhood infections may also have a beneficial effect upon childhood hearing.

摘要

背景

虽然当前的研究重点包括对年龄相关性听力损失的调查，但人们担心其对儿童听力的影响，例如通过个人耳机使用的增加。利用历史数据，可以评估过去哪些因素可能增加了儿童的听力问题，这可用于为当前的公共卫生政策提供信息，以保护儿童免受听力损失，并进而减轻可能演变的个人和服务的长期负担。本研究的目的是利用1947年出生队列的纽卡斯尔千户家庭研究的现有数据，调查早年生活中的哪些因素对儿童期听力水平有显著影响。

方法

整理了该队列中具有代表性的个体子集（n = 147）的早年生活因素数据，包括生长、社会经济状况和疾病，以及14岁时的听力数据。使用线性回归分析评估因素，以确定与听力阈值的关联。

结果

发现男性在250Hz、500Hz和1kHz时的听力阈值较低。主要分析表明，听力阈值与早年生长或社会经济指标之间没有关联。从出生到13岁耳部感染数量的增加与250Hz（p = 0.04）和500Hz（p = 0.03）的听力阈值相关，在性别特异性分析中，女性（p = 0.050）仍然如此，但男性（p = 0.213）并非如此。猩红热和支气管炎与8kHz的听力阈值相关。在对每个频率的所有显著预测因素进行调整后，结果保持不变。