Department of Neurology, Stritch School of Medicine, Loyola University Chicago, Maguire Center, Suite 2700, 2160 South First Avenue, Maywood, IL 60153, USA.
Neurol Clin. 2013 Aug;31(3):785-98. doi: 10.1016/j.ncl.2013.04.001. Epub 2013 May 18.
Despite advances in the medical and surgical therapy for epilepsy, about 30% of patients do not achieve full seizure control. In the past 5 years new antiepileptic drugs have been approved for clinical use. Some of these drugs have unique, novel mechanisms of action. Overall efficacy of these agents, however, seems similar to other antiepileptic drugs. Vagus nerve stimulation is a well-established palliative therapy for medically resistant epilepsy. Neurostimulation, with newer devices and targets becoming available, is a rapidly expanding field in epileptology. Considerable development and research are still necessary before these newer techniques become the standard of care for the treatment of epilepsy.
尽管在癫痫的医学和外科治疗方面取得了进展，但仍有约 30%的患者无法实现完全控制癫痫发作。在过去的 5 年中，新的抗癫痫药物已被批准用于临床。其中一些药物具有独特的、新颖的作用机制。然而，这些药物的总体疗效似乎与其他抗癫痫药物相似。迷走神经刺激是一种经过验证的治疗药物难治性癫痫的姑息疗法。神经刺激技术，随着新型设备和靶目标的出现，是癫痫学领域一个迅速发展的领域。在这些新技术成为治疗癫痫的标准之前，还需要进行大量的开发和研究。
