Gonçalves Cristina Borim Codo Dias, Silva Ivani Novato, Tanure Mariella Guarino, Bahia Magda
Programa de Pós-Graduação em Endocrinologia Pediátrica, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
Arq Bras Endocrinol Metabol. 2013 Jul;57(5):375-80. doi: 10.1590/s0004-27302013000500007.
To estimate the prevalence of celiac disease (CD) in children and adolescents with type 1 diabetes mellitus (T1DM) treated in the Children's Division of Endocrinology, at the Universidade Federal de Minas Gerais Hospital das Clínicas.
Children and adolescents diagnosed with T1DM, aged 0 to 18 year, were included in this study performed from March 1999 to April 2009. All patients were screened for CD at their first visit and, again, annually. The investigation was performed through the measurement of IgA (AGAA) and IgG (AGAG) antigliadin antibodies. Patients with values of AGAA and/or AGAG above two times the cutoff mark undertook intestinal biopsy.
A group of 21 patients were excluded from the initial total of 384 patients. Out of the remaining, 50 patients had positive serology and 29 underwent intestinal biopsy. The prevalence index was 3.1%.
The periodic screening of CD in diabetic patients should be encouraged, due to its high prevalence.
评估在米纳斯吉拉斯联邦大学临床医院内分泌科儿童部接受治疗的1型糖尿病（T1DM）儿童及青少年中乳糜泻（CD）的患病率。
本研究纳入了1999年3月至2009年4月期间诊断为T1DM的0至18岁儿童及青少年。所有患者在首次就诊时以及每年均接受CD筛查。通过检测抗麦胶蛋白抗体IgA（AGAA）和IgG（AGAG）进行调查。AGAA和/或AGAG值高于临界值两倍的患者接受肠道活检。
最初的384例患者中有21例被排除。其余患者中，50例血清学检查呈阳性，29例接受了肠道活检。患病率为3.1%。
鉴于糖尿病患者中CD的高患病率，应鼓励对其进行定期筛查。
