Holding Joanne C, Tarrier Nicholas, Gregg Lynsey, Barrowclough Christine
Division of Clinical Psychology, School of Psychological Sciences, University of Manchester, Manchester, England.
J Nerv Ment Dis. 2013 Aug;201(8):653-8. doi: 10.1097/NMD.0b013e31829c4ffc.
This study investigated the association between an interview-based measure of self-esteem and subsequent clinical outcome in recent-onset schizophrenia. A cohort 5-year follow-up design with retrospective chart assessment of clinical outcomes was used. Relapse rates during 5 years were very high, with 92% of the sample relapsing. Self-esteem consisted of two dimensions, negative evaluation of self (NES) and positive evaluation of self (PES). Survival analysis indicated that high NES was significantly associated with shorter time to relapse; and PES, with longer survival time. The participants with high PES were three times more likely to have delayed relapse; no other covariates were significant. PES seemed to buffer the adverse effects of NES. The results indicate that social cognition in the form of self-evaluation may be implicated in clinical outcome and symptom exacerbation in schizophrenia.This study investigated the association between an interview-based measure of self-esteem and subsequent clinical outcome in recent-onset schizophrenia. A cohort 5-year follow-up design with retrospective chart assessment of clinical outcomes was used. Relapse rates during 5 years were very high, with 92% of the sample relapsing. Self-esteem consisted of two dimensions, negative evaluation of self (NES) and positive evaluation of self (PES). Survival analysis indicated that high NES was significantly associated with shorter time to relapse; and PES, with longer survival time. The participants with high PES were three times more likely to have delayed relapse; no other covariates were significant. PES seemed to buffer the adverse effects of NES. The results indicate that social cognition in the form of self-evaluation may be implicated in clinical outcome and symptom exacerbation in schizophrenia.
本研究调查了基于访谈的自尊测量与近期发病精神分裂症患者后续临床结局之间的关联。采用了队列5年随访设计，并对临床结局进行回顾性图表评估。5年期间的复发率非常高，样本中有92%复发。自尊由两个维度组成，即对自我的负面评价（NES）和对自我的正面评价（PES）。生存分析表明，高NES与较短的复发时间显著相关；而PES与较长的生存时间相关。PES高的参与者复发延迟的可能性是其他参与者的三倍；没有其他协变量具有显著性。PES似乎可以缓冲NES的不良影响。结果表明，以自我评价形式存在的社会认知可能与精神分裂症的临床结局和症状加重有关。本研究调查了基于访谈的自尊测量与近期发病精神分裂症患者后续临床结局之间的关联。采用了队列5年随访设计，并对临床结局进行回顾性图表评估。5年期间的复发率非常高，样本中有92%复发。自尊由两个维度组成，即对自我的负面评价（NES）和对自我的正面评价（PES）。生存分析表明，高NES与较短的复发时间显著相关；而PES与较长的生存时间相关。PES高的参与者复发延迟的可能性是其他参与者的三倍；没有其他协变量具有显著性。PES似乎可以缓冲NES的不良影响。结果表明，以自我评价形式存在的社会认知可能与精神分裂症的临床结局和症状加重有关。
