Jiménez-León Juan C, Betancourt-Fursow Yaline M, Jiménez-Betancourt Cristina S
Centro Policlinico Valencia, Valencia, Venezuela.
Rev Neurol. 2013 Sep 6;57 Suppl 1:S37-45.
Congenital malformations of the central nervous system are related to alterations in neural tube formation, including most of the neurosurgical management entities, dysraphism and craniosynostosis; alterations of neuronal proliferation; megalencefaly and microcephaly; abnormal neuronal migration, lissencephaly, pachygyria, schizencephaly, agenesis of the corpus callosum, heterotopia and cortical dysplasia, spinal malformations and spinal dysraphism. We expose the classification of different central nervous system malformations that can be corrected by surgery in the shortest possible time and involving genesis mechanisms of these injuries getting better studied from neurogenic and neuroembryological fields, this involves connecting innovative knowledge areas where alteration mechanisms in dorsal induction (neural tube) and ventral induction (telencephalization) with the current way of correction, as well as the anomalies of cell proliferation and differentiation of neuronal migration and finally the complex malformations affecting the posterior fossa and current possibilities of correcting them.
中枢神经系统先天性畸形与神经管形成的改变有关，包括大多数神经外科治疗的病症、脊柱裂和颅缝早闭；神经元增殖的改变；巨脑症和小头症；神经元迁移异常、无脑回畸形、巨脑回畸形、脑裂畸形、胼胝体发育不全、异位症和皮质发育异常、脊柱畸形和脊柱裂。我们阐述了不同中枢神经系统畸形的分类，这些畸形可在尽可能短的时间内通过手术矫正，并且涉及从神经发生学和神经胚胎学领域对这些损伤的发生机制进行更好的研究，这涉及将背侧诱导（神经管）和腹侧诱导（端脑形成）的改变机制与当前的矫正方法相联系的创新知识领域，以及细胞增殖和神经元迁移分化的异常，最后是影响后颅窝的复杂畸形及其当前的矫正可能性。
