生发中心抗原（包括 LMO2）的免疫组织架构模式有助于边缘区淋巴瘤与滤泡性淋巴瘤的鉴别诊断。
Immunoarchitectural patterns of germinal center antigens including LMO2 assist in the differential diagnosis of marginal zone lymphoma vs follicular lymphoma.
机构信息
Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
出版信息
Am J Clin Pathol. 2013 Aug;140(2):149-54. doi: 10.1309/AJCPHPVH4M7MTWUN.
OBJECTIVES
To examine the immunoarchitectural patterns of the germinal center (GC)-associated markers CD10, BCL6, and LMO2 and their utility in the differential diagnosis of marginal zone lymphoma (MZL) vs follicular lymphoma (FL).
METHODS
Forty-two cases of MZL involving lymph nodes and 88 cases of FL were examined.
RESULTS
Interfollicular staining for GC markers was uncommon in MZL but common in FL, including BCL2-positive and BCL2-negative cases. Two atypical patterns of intrafollicular GC staining were identified that were more common in MZL than in FL.
CONCLUSIONS
Staining for LMO2 in addition to CD10 and BCL6 facilitates the detection of a GC phenotype in FL. Lymph nodes involved by MZL frequently show characteristic alterations of GC immunoarchitecture. Recognizing these altered patterns assists in the distinction between MZL and FL.
目的
研究生发中心（GC）相关标志物 CD10、BCL6 和 LMO2 的免疫组织化学模式，并探讨其在鉴别诊断边缘区淋巴瘤（MZL）与滤泡性淋巴瘤（FL）中的作用。
方法
本研究纳入了 42 例淋巴结 MZL 病例和 88 例 FL 病例。
结果
MZL 中常见生发中心标志物的滤泡间染色，而在 FL 中则不常见，包括 BCL2 阳性和 BCL2 阴性病例。还发现了两种更常见于 MZL 而非 FL 的滤泡内 GC 染色的非典型模式。
结论
除了 CD10 和 BCL6 之外，LMO2 的染色有助于在 FL 中检测 GC 表型。MZL 累及的淋巴结常表现出 GC 免疫组织化学模式的特征性改变。识别这些改变的模式有助于区分 MZL 和 FL。
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