根据 FAB 分类，难治性贫血骨髓增生异常综合征患者中，发育异常谱系与细胞减少类型之间的相关性。
Correlation between dysplastic lineage and type of cytopenia in myelodysplastic syndromes patients with refractory anemia according to the FAB classification.
机构信息
Department of Hemato-Oncology, Saitama International Medical Center, Saitama Medical University, 1397-1 Yamane, Hidaka, Saitama, 350-1298, Japan.
出版信息
Am J Clin Pathol. 2013 Aug;140(2):253-7. doi: 10.1309/AJCPJEFPNTMM3KSH.
OBJECTIVES
To analyze the correlation between dysplastic lineage and type of cytopenia in myelodysplastic syndromes.
METHODS
We analyzed the correlation between dysplasia and cell count using the data set of our previous morphologic study.
RESULTS
There were no correlations between dysgranulopoiesis of 10% or more and absolute neutrophil count (ANC). Similarly, hyposegmented mature neutrophils (Pelger) of 10% or more were not related to ANC. Interestingly, the platelet count of patients with dysmegakaryopoiesis (dys Mgk) was higher than that of patients without dys Mgk (dys Mgk ≥10% vs <10%, P = .08; dys Mgk ≥40% vs <40%, P = .02; micromegakaryocytes ≥10% vs <10%, P = .004).
CONCLUSIONS
Since low cell counts did not correlate with the presence of dysplastic features, we suggest that dysplastic features do not directly relate to apoptosis.
目的
分析骨髓增生异常综合征中病态造血与细胞减少类型的相关性。
方法
我们使用之前形态学研究的数据组来分析病态造血与细胞计数之间的相关性。
结果
大于等于 10%的粒系病态造血与绝对中性粒细胞计数（ANC）无相关性。同样，大于等于 10%的核分叶减少的成熟中性粒细胞（Pelger）也与 ANC 无关。有趣的是，具有病态巨核细胞生成（dys Mgk）的患者的血小板计数高于无 dys Mgk 的患者（dys Mgk ≥10%与<10%相比，P =.08；dys Mgk ≥40%与<40%相比，P =.02；大于等于 10%的微小巨核细胞与<10%相比，P =.004）。
结论
由于低细胞计数与病态造血特征的存在无关，因此我们认为病态造血特征与细胞凋亡并无直接关系。
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