Department of Clinical Sciences Lund, Section of Rheumatology, Lund University, Lund, Sweden.
Epi-centre Skåne, Skåne University Hospital, Lund, Sweden Department of Orthopedics, Clinical Sciences Lund, Lund University, Lund, Sweden.
Ann Rheum Dis. 2014 Oct;73(10):1788-92. doi: 10.1136/annrheumdis-2013-203618. Epub 2013 Jul 29.
To estimate the prevalence and incidence of systemic sclerosis (SSc) in southern Sweden.
In Skåne, the southernmost region of Sweden (total population 1.2 million), healthcare provided is registered in the Skåne Healthcare Register. We identified all Skåne residents who had received an International Classification of Diseases 10 diagnosis of SSc (M34) or Raynaud's phenomenon (I73.0) between 1998 and 2010. Every single case was ascertained by review of medical records in reference to the 1980 American Rheumatism Association preliminary classification criteria for SSc and the proposed American College of Rheumatology (ACR)-European League Against Rheumatism (EULAR) classification criteria presented at the ACR/Association of Rheumatology Health Professionals Annual Meeting 2012. We calculated the point prevalence by the end of 2010 by linkage with the population register to exclude deceased persons and we also estimated the mean annual cumulative incidence for 2006-2010.
Using the 1980 ARA criteria, the adult prevalence and annual incidence of SSc in the Skåne region were 235 and 14 per 1 million inhabitants respectively. Applying the proposed ACR-EULAR criteria, the corresponding figures were 305 and 19 per 1 million inhabitants. A majority (82%) of the prevalent cases had the limited cutaneous SSc subtype.
The prevalence and incidence of SSc in southern Sweden, based on the 1980 ARA criteria, are higher than previously reported in northern Europe and do not support the concept of a north-south gradient of SSc occurrence in Europe. Application of the proposed ACR-EULAR classification criteria in this population results in about 30-40% higher estimates of SSc prevalence and incidence compared to the 1980 ARA criteria.
估计瑞典南部系统性硬化症（SSc）的患病率和发病率。
在瑞典最南端的斯科讷地区（总人口 120 万），医疗保健由斯科讷医疗登记处登记。我们确定了在 1998 年至 2010 年间在斯科讷接受过国际疾病分类第 10 版 SSc（M34）或雷诺现象（I73.0）诊断的所有斯科讷居民。每例病例均通过审查病历来确定，参考 1980 年美国风湿病学会初步 SSc 分类标准和 2012 年美国风湿病学会/风湿病专业人员协会年会提出的美国风湿病学会-欧洲抗风湿病联盟（EULAR）分类标准。我们通过与人口登记处的联系来计算 2010 年底的时点患病率，以排除死亡人数，我们还估计了 2006-2010 年的平均年累积发病率。
使用 1980 年 ARA 标准，斯科讷地区成年人 SSc 的患病率和年发病率分别为 235 和 14/100 万居民。应用建议的 ACR-EULAR 标准，相应的数字分别为 305 和 19/100 万居民。大多数（82%）现患病例为局限性皮肤 SSc 亚型。
根据 1980 年 ARA 标准，瑞典南部 SSc 的患病率和发病率高于北欧先前的报告，这并不支持欧洲 SSc 发生存在南北梯度的概念。在该人群中应用建议的 ACR-EULAR 分类标准，与 1980 年 ARA 标准相比，SSc 的患病率和发病率估计值高出约 30-40%。
