Department of Internal Medicine, University of Nebraska Medical Center, Omaha. NE 68198-2055, USA.
Anticancer Res. 2013 Aug;33(8):3263-8.
Herpes simplex virus 1 (HSV-1) is the principal cause of viral necrotizing encephalitis in developed countries. Small cell carcinoma of the lung accounts for about 15% of all lung cancer. HSV induced encephalitis (HSE) following prophylactic cranial irradiation (PCI) in SCLC is rare. Here, we describe the case of a 58-year-old woman with limited stage SCLC, multiple sclerosis (MS) and cutaneous lupus who developed fatal HSE following PCI. We review the literature to investigate the inter-relationships between these diseases and management of HSE.
单纯疱疹病毒 1 型（HSV-1）是发达国家病毒性坏死性脑炎的主要病因。小细胞肺癌约占所有肺癌的 15%。预防性颅脑照射（PCI）后小细胞肺癌（SCLC）引起单纯疱疹病毒脑炎（HSE）较为罕见。在此，我们描述了一例局限期 SCLC、多发性硬化症（MS）和皮肤狼疮的 58 岁女性，在接受 PCI 后发生致命性 HSE 的病例。我们回顾了文献，以探讨这些疾病之间的相互关系和 HSE 的治疗。
