Valverde A, Honeyman V L, Dyson D H, Valliant A E
Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Canada.
Am J Vet Res. 1990 Jul;51(7):1071-4.
Midazolam HCl (1.0 or 2.0 mg/kg of body weight) was administered IM to 6 Canada geese to determine a sedative dose that would allow positioning for radiologic examination. The effects of both test doses on cardiopulmonary function were evaluated at 5, 10, 15, 20, 30, and 40 minutes after drug administration and were compared with 2 end-tidal isoflurane concentrations (1.5 and 2.5%). The 2.0 mg/kg dosage induced moderate sedation at 15 and 20 minutes; sedation was adequate for positioning the geese. Sedation induced by the 1.0 mg/kg dosage was inadequate. The effects of both test doses on blood pressure, heart rate, and temperature were not significantly different from each other and from baseline data. Respiratory rate increased significantly (P less than 0.05) at 10, 15, 20, and 30 minutes with the 2.0 mg/kg dosage, and at 15 and 20 minutes with the 1.0 mg/kg dosage. Blood pressure and respiratory rate were significantly (P less than 0.05) decreased with isoflurane when compared with baseline data and the midazolam test doses. The results of this study indicate that midazolam at a dosage of 2.0 mg/kg induces adequate sedation with minimal cardiopulmonary changes, and, as an alternative to general anesthesia with isoflurane, provides a satisfactory level of restraint for radiography.
将盐酸咪达唑仑（1.0或2.0毫克/千克体重）肌肉注射给6只加拿大鹅，以确定能使其保持适合放射检查姿势的镇静剂量。在给药后5、10、15、20、30和40分钟评估两种测试剂量对心肺功能的影响，并与两种呼气末异氟烷浓度（1.5%和2.5%）进行比较。2.0毫克/千克的剂量在15和20分钟时诱导出中度镇静；这种镇静程度足以让鹅保持姿势。1.0毫克/千克剂量诱导的镇静效果不佳。两种测试剂量对血压、心率和体温的影响彼此之间以及与基线数据相比均无显著差异。2.0毫克/千克剂量在10、15、20和30分钟时，以及1.0毫克/千克剂量在15和20分钟时，呼吸频率显著增加（P<0.05）。与基线数据和咪达唑仑测试剂量相比，异氟烷使血压和呼吸频率显著降低（P<0.05）。本研究结果表明，2.0毫克/千克剂量的咪达唑仑可诱导足够的镇静，且心肺变化最小，作为异氟烷全身麻醉的替代方法，可为放射摄影提供令人满意的约束水平。
