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1例右肾盂输尿管癌伴肝转移经M-VAC方案治疗后完全缓解

[A case of right renal pelvic and ureter cancer with hepatic metastasis showing complete response by M-VAC].

作者信息

Sumiyoshi Y, Akiyama K, Yano M

机构信息

Dept. of Urology, Shikoku Cancer Center.

出版信息

Gan To Kagaku Ryoho. 1990 Aug;17(8 Pt 1):1521-3.

PMID:2389946
Abstract

A 69-year-old man was admitted for further examination of right hydronephrosis in November 1988. Radiologically, excretory urography showed right non-functional kidney and antegrade pyelography revealed filling defect of right renal pelvis and ureter. Cytology findings of right renal urine indicated transitional cell carcinoma. Computed tomography revealed multiple mass of liver. The patient was administered M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) combination chemotherapy. After the 4 courses of treatment, the mass of the primary lesion and hepatic metastasis disappeared and he achieved complete remission. The side effects noted were mild myelosuppression, alopecia and gastrointestinal symptoms such as nausea and vomiting.

摘要

一名69岁男性于1988年11月因右肾积水接受进一步检查。放射学检查显示,排泄性尿路造影显示右肾无功能,顺行肾盂造影显示右肾盂和输尿管充盈缺损。右肾尿液的细胞学检查结果提示移行细胞癌。计算机断层扫描显示肝脏有多个肿块。该患者接受了M-VAC(甲氨蝶呤、长春花碱、阿霉素和顺铂)联合化疗。经过4个疗程的治疗,原发灶和肝转移灶消失,患者实现完全缓解。观察到的副作用为轻度骨髓抑制、脱发以及恶心、呕吐等胃肠道症状。

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