Sumiyoshi Y, Yano M, Yokota K, Akiyama M, Uyama T
Dept. of Urology, Shikoku Cancer Center.
Gan To Kagaku Ryoho. 1990 Aug;17(8 Pt 2):1697-700.
Between 1976 and 1985, 35 patients with bladder cancer were preoperatively treated with intra-arterial doxorubicin (ADM) chemotherapy. We separated these patients into 2 groups according to regimen: A) 1-3 shots of ADM infusion with or without radiotherapy, and B) 3-day courses of ADM infusion with low-dose radiotherapy. The 5-year actual survival rate according to stage (T category) was 100% in T1-2, 37.5% in T3 and 23.3% in T4. In T1-2, bladder preservative operations were done on 50% of the patients in group A and 100% in group B. In T3-4, the 5-year actual survival rate in group A was 22.5%, while in group B it was 52.8% (p less than 0.01). The bladder preservative operations were done on 33.3% of the patients in group A and 73.3% in group B. The patients who received ADM intra-arterial chemotherapy combined with low-dose radiotherapy for bladder cancers, who achieved complete or partial remission, might be able to preserve their bladder.
1976年至1985年间，35例膀胱癌患者术前行动脉内阿霉素（ADM）化疗。我们根据治疗方案将这些患者分为两组：A组）1 - 3次ADM灌注，联合或不联合放疗；B组）3天疗程的ADM灌注加低剂量放疗。根据分期（T分类）的5年实际生存率，T1 - 2期为100%，T3期为37.5%，T4期为23.3%。在T1 - 2期，A组50%的患者和B组100%的患者接受了膀胱保留手术。在T3 - 4期，A组的5年实际生存率为22.5%，而B组为52.8%（p小于0.01）。A组33.3%的患者和B组73.3%的患者接受了膀胱保留手术。接受动脉内阿霉素化疗联合低剂量放疗且达到完全或部分缓解的膀胱癌患者可能能够保留膀胱。
