Nuclear Medicine Division, Indian Institute of Chemical Biology (CSIR), 4, Raja S. C. Mullick Road, Jadavpur, Kolkata-700 032, India.
Dalton Trans. 2013 Oct 7;42(37):13565-75. doi: 10.1039/c3dt50928a. Epub 2013 Jul 30.
Radiolabeled complexes of monoamino polycarboxylic, polyamino monocarboxylic and thiol containing amino acid ligands were prepared from a fac-(99m)Tc(CO)3(H2O)3 precursor.The overall radiochemical yield was 94-98%. The complexes exhibited substantial in vitro and in vivo stability. The corresponding Re(I) complexes of the ligands DAPA, Asp and CysH were prepared and characterized by means of IR, NMR, and MS spectroscopic studies, as well as X-ray crystallography (for those containing D,L-DAPA and D,L-Asp). The rhenium complexes have been structurally correlated with the technetium complexes by means of HPLC studies. The reaction of Re(CO)5Cl with D,L-Asp in presence of triethylamine led to the formation of a new class of cyclic dimeric complexes formed by the OON donor atom set of the tridentate ligands. The amino carboxylate ligand system formed well defined complexes with a fac-M(CO)3(H2O)3 core and shows good promise in (99m)Tc(CO)3 tracer development.
放射性标记的单氨基多羧酸、多氨基单羧酸和含巯基氨基酸配体的配合物是由 fac-(99m)Tc(CO)3(H2O)3前体制备的。总放射化学收率为 94-98%。配合物表现出很大的体外和体内稳定性。配体 DAPA、Asp 和 CysH 的相应 Re(I)配合物通过 IR、NMR 和 MS 光谱研究以及 X 射线晶体学（对于那些含有 D,L-DAPA 和 D,L-Asp 的配合物）进行了表征。通过 HPLC 研究将 Re 配合物与技术配合物进行了结构相关。在三乙胺存在下，Re(CO)5Cl 与 D,L-Asp 反应生成了一类新的由三齿配体的 OON 供体原子组形成的环状二聚体配合物。氨基羧酸盐配体系统与 fac-M(CO)3(H2O)3核形成了定义良好的配合物，并在（99m)Tc(CO)3 示踪剂开发中显示出良好的前景。
