Mujtaba Shafaq, Haroon Saroona, Faridi Naveen, Lodhi Faisal Rashid
Department of Pathology, Liaquat National Hospital, The Aga Khan University, Karachi.
J Pak Med Assoc. 2013 Jul;63(7):854-8.
To determine the frequency of human epidermal growth factor receptor 2 (HER-2/neu) positivity and to correlate its status in breast cancer patients with other prognostic markers.
The comparative cross-sectional study was conducted at the Department of Histopathology, Liaquat National Hospital, Karachi, from January 1 to October 31, 2010. It included all specimens of mastectomy and lumpectomy with axillary tissue. Incisional, trucut and wedge biopsies as well as all non-epithelial tumours were excluded. All samples were processed as per standard guidelines and were evaluated by immunohistochemistry. SPSS 10 was used for statistical analysis.
The age of the 100 cases in the study ranged from 20 to 82 years with a mean of 51+/-17.6 years. Two (2%) of the patients were males. HER-2/neu over-expression increased with increasing tumour size, grade, lymph node metastasis and with oestrogen receptor and progesterone receptor negativity. No significant correlation of HER-2/neu was seen with the age of patient and with the tumour type.
The expression of HER-2/neu was associated with decrease in oestrogen receptor and progresterone receptor positivity, and increase in tumour size, high tumour grade and lymph node metastasis.
确定人表皮生长因子受体2（HER-2/neu）阳性的频率，并将乳腺癌患者中其状态与其他预后标志物相关联。
这项比较性横断面研究于2010年1月1日至10月31日在卡拉奇利亚卡特国家医院组织病理学系进行。研究包括所有乳房切除术和肿块切除术及腋窝组织标本。排除切开活检、针吸活检和楔形活检以及所有非上皮性肿瘤。所有样本均按照标准指南进行处理，并通过免疫组织化学进行评估。使用SPSS 10进行统计分析。
该研究中100例患者的年龄范围为20至82岁，平均年龄为51±17.6岁。两名（2%）患者为男性。HER-2/neu过表达随肿瘤大小、分级、淋巴结转移增加以及雌激素受体和孕激素受体阴性而增加。未发现HER-2/neu与患者年龄及肿瘤类型有显著相关性。
HER-2/neu的表达与雌激素受体和孕激素受体阳性率降低以及肿瘤大小增加、肿瘤分级高和淋巴结转移有关。
