Rahaus Markus, Augustinski Karsten, Castells Marc, Desloges Nathalie
Lohmann Animal Health GmbH, Heinz-Lohmann Str. 4, 27472, Cuxhaven, Germany.
Avian Dis. 2013 Jun;57(2 Suppl):498-502. doi: 10.1637/10334-082712-Reg.1.
A possible interference after Marek's disease (MD) vaccination using an experimental bivalent vaccine, consisting of a redesigned CVI-988/Rispens-type MDV-1 strain and herpesvirus of turkeys, with vaccination against infectious bronchitis (IB) virus (IBV) or Newcastle disease (ND) virus (NDV) was examined. Day-old specific-pathogen-free chicks were concomitantly vaccinated with the bivalent MD vaccine (either intramuscularly or subcutaneously) and with commercially available vaccines against ND or IB. Afterward chickens were challenged with either lethal MD virus (MDV) or NDV strains or with a pathogenic IBV strain. After challenge, neither mortality nor notable clinical signs of MD, ND, or IB were observed in the vaccinated birds. The experimental bivalent MDV vaccine proved efficacious against lethal MDV challenge and did not affect the efficacy of the NDV or IBV vaccines. In conclusion, no signs of interference or adverse effects were detected. Thus, the vaccines can be administered concomitantly on chickens' first day of life.
使用一种实验性二价疫苗进行马立克氏病（MD）疫苗接种后可能存在的干扰情况得到了研究。该二价疫苗由重新设计的CVI - 988/里氏MDV - 1毒株和火鸡疱疹病毒组成，同时还对接种传染性支气管炎（IB）病毒（IBV）或新城疫（ND）病毒（NDV）进行了研究。一日龄无特定病原体雏鸡同时接种二价MD疫苗（肌肉注射或皮下注射）以及市售的抗ND或IB疫苗。之后，用致死性MD病毒（MDV）或NDV毒株或致病性IBV毒株对鸡进行攻毒。攻毒后，接种疫苗的鸡未观察到MD、ND或IB的死亡或明显临床症状。实验性二价MDV疫苗被证明对致死性MDV攻毒有效，且不影响NDV或IBV疫苗的效力。总之，未检测到干扰或不良反应的迹象。因此，这些疫苗可在雏鸡出生第一天同时接种。
