Khazardoost Soghra, Mousavi Sanaz, Borna Sedigheh, Hantoushzadeh Sedigheh, Alavi Azin, Khezerlou Naser
Perinatology Division, OB/GYN Department, Tehran University of Medical Sciences , Tehran , Islamic Republic of Iran.
J Matern Fetal Neonatal Med. 2014 Apr;27(6):561-5. doi: 10.3109/14767058.2013.822483. Epub 2013 Aug 7.
To evaluate the effect of low-dose aspirin in prevention of adverse pregnancy outcomes (APO) in women with second trimester alpha-fetoprotein (AFP) >2.5 multiple of median (MOM) and to compare aspirin effect on women with normal and abnormal uterine artery (UtA) Doppler. The primary outcome was the adverse pregnancy outcome.
This randomized controlled trial was conducted in singleton pregnant women, who had unexplained AFP >2.5 MOM and gestational age between 15 and 18 weeks of gestation. They were assigned randomly to receive either aspirin (N = 65) or control (N = 68). UtA Doppler velocimetry studies were performed at the time of targeted ultrasonographic exam.
Two groups were comparable regarding the maternal characteristics. The frequency of APO in aspirin and control groups were 26.1% versus 44.1% (p = 0.045), the frequency of preterm delivery before 34 weeks were 3.2% versus 22.0% in aspirin and control group, p = 0.001. Other outcomes were similar in both groups. The frequency of adverse outcomes in women with abnormal UtA Doppler was 39.1% in aspirin and 60.0% in control group, p = 0.556.
Low-dose aspirin reduces APO and delivery before 34 weeks of gestation in pregnant women with unexplained elevated AFP.
评估低剂量阿司匹林对孕中期甲胎蛋白（AFP）>2.5倍中位数（MOM）的女性预防不良妊娠结局（APO）的效果，并比较阿司匹林对子宫动脉（UtA）多普勒正常和异常女性的影响。主要结局为不良妊娠结局。
本随机对照试验纳入单胎妊娠妇女，她们的AFP原因不明地>2.5MOM且孕龄在妊娠15至18周之间。将她们随机分配接受阿司匹林治疗（N = 65）或对照治疗（N = 68）。在进行靶向超声检查时进行UtA多普勒测速研究。
两组产妇特征具有可比性。阿司匹林组和对照组的APO发生率分别为26.1%和44.1%（p = 0.045），阿司匹林组和对照组34周前早产发生率分别为3.2%和22.0%，p = 0.001。两组的其他结局相似。UtA多普勒异常的女性中，阿司匹林组不良结局发生率为39.1%，对照组为60.0%，p = 0.556。
低剂量阿司匹林可降低原因不明AFP升高的孕妇的APO及34周前分娩率。
