Pulmonary Department-Oncology Unit, G Papanikolaou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Future Oncol. 2013 Aug;9(8):1171-94. doi: 10.2217/fon.13.67.
Lung cancer still remains one of the leading causes of death among cancer patients. Although novel targeted therapies have been established in everyday treatment practice, and conventional platinum-based doublets have demonstrated effective results regarding overall and progression-free survival, we have still failed to achieve long-term survival. Therefore, several strategies of applying locoregional therapy are under investigation. Aerosol chemotherapy is already under investigation and, taking this a step further, aerosol gene therapies with multiple delivery systems are being developed. Several efforts have demonstrated its efficiency and effectiveness, but there are still multiple factors that have to be considered and combined to achieve an overall more effective multifunctional treatment. In the current review, we present data regarding aerosol delivery systems, transporters, carriers, vectors, genes, toxicity, efficiency, specificity, lung microenvironment and delivery gene therapy systems. Finally, we present current studies and future perspectives.
肺癌仍然是癌症患者死亡的主要原因之一。尽管新型靶向治疗已在日常治疗实践中确立，且常规铂类双联方案在总生存期和无进展生存期方面显示出有效结果，但我们仍未能实现长期生存。因此，正在研究几种局部区域治疗策略。雾化化疗已经在研究中，在此基础上，正在开发多种输送系统的雾化基因治疗。多项研究已经证明了其有效性，但仍有许多因素需要考虑并结合起来，以实现更有效的多功能治疗。在目前的综述中，我们介绍了关于气雾剂输送系统、转运体、载体、载体、基因、毒性、效率、特异性、肺微环境和输送基因治疗系统的数据。最后，我们介绍了当前的研究和未来的展望。
