以氯化中-四苯基卟啉合铬(3+)作为电化学P-450模型化合物对烯烃进行环氧化反应。
The epoxidation of the olefins by meso-tetraphenylporphyrinatochromium(3+) chloride as an electrochemical P-450 model compound.
作者信息
Michida Takashi, Omichi Takuryu
机构信息
Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Minatojima, Chuo-ku, Kobe 650–8586, Japan.
出版信息
Chem Pharm Bull (Tokyo). 2013;61(8):799-801. doi: 10.1248/cpb.c12-00806.
An electrochemical P450 model compound consisting of meso-tetraphenylporphyrinatochromium(3+) chloride (CrTPP), imidazole, and acetic acid was used in acetonitrile containing alkenes. The corresponding epoxides were obtained in better yields compared to a similar electrochemical P450 model compound using meso-tetraphenylporphyrinatomanganese(3+) chloride. The results of cyclic voltammetry and controlled potential electrolysis suggest that electrochemically reduced CrTPP reacts with dissolved oxygen to oxidize alkenes to epoxides.
一种由氯化中-四苯基卟啉铬(3+)（CrTPP）、咪唑和乙酸组成的电化学P450模型化合物被用于含烯烃的乙腈中。与使用氯化中-四苯基卟啉锰(3+)的类似电化学P450模型化合物相比，相应的环氧化物以更高的产率获得。循环伏安法和控制电位电解的结果表明，电化学还原的CrTPP与溶解氧反应将烯烃氧化为环氧化物。
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