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阿米替林致死性自服中毒后的毒理学发现。

Toxicological findings after fatal amitriptyline self-poisoning.

作者信息

Tracqui A, Kintz P, Ritter-Lohner S, Mangin P, Lugnier A, Chaumont A

机构信息

Institut de Médecine Légale, Faculté de Médecine de Strasbourg, Strasbourg, France.

出版信息

Hum Exp Toxicol. 1990 Jul;9(4):257-61. doi: 10.1177/096032719000900410.

DOI:10.1177/096032719000900410
PMID:2390323
Abstract

A case of fatal self-poisoning with amitriptyline is reported. Both the drug and its metabolite nortriptyline were quantified in several post-mortem tissues and fluids, including vitreous humor. Results are discussed in the light of the existing literature.

摘要

报告了一例因阿米替林导致的致命性自我中毒病例。在包括玻璃体液在内的多个尸检组织和体液中对该药物及其代谢产物去甲替林进行了定量分析。根据现有文献对结果进行了讨论。

相似文献

1
Toxicological findings after fatal amitriptyline self-poisoning.阿米替林致死性自服中毒后的毒理学发现。
Hum Exp Toxicol. 1990 Jul;9(4):257-61. doi: 10.1177/096032719000900410.
2
Selective determination of amitriptyline and nortriptyline in human plasma by HPLC with ultraviolet and particle beam mass spectrometry.采用高效液相色谱法结合紫外和粒子束质谱法对人血浆中的阿米替林和去甲替林进行选择性测定。
J Anal Toxicol. 1997 May-Jun;21(3):185-9. doi: 10.1093/jat/21.3.185.
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[The determination of amitriptyline and its metabolite, nortriptyline, in the biological objects of the corpse by the high-performance liquid chromatography technique].[采用高效液相色谱技术测定尸体生物样本中阿米替林及其代谢产物去甲替林]
Sud Med Ekspert. 2015 Jan-Feb;58(1):31-34. doi: 10.17116/sudmed201558131-34.
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[Fatal limbratil-F intoxication with post mortem gas chromatographic demonstration of tissue levels of amitriptyline and nortriptyline (author's transl)].[致命的利眠宁 - 氟中毒，死后气相色谱法显示组织中阿米替林和去甲替林水平（作者译）]
Dtsch Med Wochenschr. 1973 Dec 28;98(52):2472 passim. doi: 10.1055/s-0028-1107282.
5
Distribution of amitriptyline and nortriptyline in fatal amitriptyline intoxications with different survival times.不同存活时间的阿米替林致死性中毒中阿米替林和去甲替林的分布情况。
Forensic Sci. 1974 Oct;4(2):187-90. doi: 10.1016/0300-9432(74)90101-0.
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[Fatal poisoning involving amitriptyline: toxicologic data].[涉及阿米替林的致命中毒：毒理学数据]
J Toxicol Clin Exp. 1992 Mar;12(1):3-9.
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Massive intoxication involving unusual high concentration of amitriptyline.大量中毒，涉及异常高浓度的阿米替林。
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[Serum levels of amitriptyline and nortriptyline in a case of poisoning].[一例中毒病例中阿米替林和去甲替林的血清水平]
Med Clin (Barc). 1985 May 18;84(19):798-9.
9
Concentrations of amitriptyline and its metabolites in urine, blood and tissue in fatal amitriptyline poisoning.
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Two tricyclic antidepressant poisonings: levels of amitriptyline, nortriptyline and desipramine in post-mortem biological samples.两例三环类抗抑郁药中毒：死后生物样本中阿米替林、去甲替林和地昔帕明的含量
Forensic Sci Int. 1987 Feb;33(2):93-101. doi: 10.1016/0379-0738(87)90145-9.

引用本文的文献

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Brain concentrations and brain-blood ratios of amitriptyline and nortriptyline in forensic postmortem cases.法医尸检案例中阿米替林和去甲替林的脑浓度及脑血比
J Anal Toxicol. 2025 Apr 12;49(4):209-215. doi: 10.1093/jat/bkaf017.
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Vitreous humor analysis for the detection of xenobiotics in forensic toxicology: a review.用于法医毒理学中检测外源性物质的玻璃体液分析：综述
Forensic Toxicol. 2016;34:12-40. doi: 10.1007/s11419-015-0294-5. Epub 2015 Oct 28.