School of Chemistry, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
Org Biomol Chem. 2013 Sep 21;11(35):5877-84. doi: 10.1039/c3ob41112e.
Aryl(alkynyl)iodonium salts have been demonstrated to be valuable precursors to a diverse range of heteroaromatic ring systems including aryl[1,2-a]imidazopyridines. Successful application, using the recently described aryl(alkynyl)iodonium trifluoroacetate salts, is described, highlighting for the first time that the regioselectivity of this process is both counter-ion and concentration dependent. Studies with a carbon-13 labelled substrate established that the reactions of alkynyliodonium salts are highly complex and that multiple mechanistic processes appear to be underway simultaneously.
芳基（炔基）碘𬭩盐已被证明是制备各种杂芳环体系的有价值的前体，包括芳基[1,2-a]咪唑并吡啶。成功地应用了最近描述的芳基（炔基）碘𬭩三氟乙酸盐，首次强调了该过程的区域选择性既依赖于反离子又依赖于浓度。使用 13C 标记的底物进行的研究表明，炔基碘𬭩盐的反应非常复杂，似乎同时进行多种机理过程。
