Department of Biological Sciences, Simon Fraser University, 8888 University Dr., Burnaby, BC, V5A 1S6, Canada,
Bull Environ Contam Toxicol. 2013 Oct;91(4):455-9. doi: 10.1007/s00128-013-1070-z. Epub 2013 Aug 1.
Embryonic toxicity of a brominated flame retardant, TBECH (1,2-dibromo-4-(1, 2-dibromoethyl) cyclohexane) was investigated using the zebra finch (Taeniopygia guttata) as our model. Using in ovo dosing procedures, we injected the technical TBECH compound, consisting of 50:50 α-/β-isomers, directly into the yolk of freshly laid eggs at concentrations of 2.3-94 ng/g egg. No significant effects were observed in terms of growth or survival for either pre-hatch embryos or post-hatch chicks. Analysis of tissue samples at various developmental stages suggests that α-/β-TBECH was metabolized rapidly, and thus is unlikely to cause any direct, long-term effects on the development of zebra finch embryos or offspring.
我们选用斑胸草雀（Taeniopygia guttata）作为模型，研究了一种溴化阻燃剂 TBECH（1,2-二溴-4-（1,2-二溴乙基）环己烷）的胚胎毒性。通过胚胎注射的方法，我们将含有 50:50α-/β-异构体的 TBECH 技术混合物以 2.3-94ng/g 卵的浓度直接注射到新产下的卵黄中。无论是孵化前的胚胎还是孵化后的雏鸟，其生长或存活均未受到显著影响。对不同发育阶段的组织样本进行分析表明，α-/β-TBECH 被快速代谢，因此不太可能对斑胸草雀胚胎或后代的发育造成任何直接的长期影响。
