Department of Clinical Radiology, University Hospital Münster, Albert-Schweitzer-Campus 1, Building A1, 48149, Münster, Germany,
Eur Radiol. 2013 Oct;23(10):2868-79. doi: 10.1007/s00330-013-2895-x. Epub 2013 Aug 1.
SWI can help to identify high-grade gliomas (HGG). The objective of this study was to analyse SWI and CE-SWI characteristics, i.e. the relationship between contrast-induced phase shifts (CIPS) and intratumoral susceptibility signals (ITSS) and their association with tumour volume in patients with glioblastoma multiforme (GBM).
MRI studies of 29 patients were performed to evaluate distinct susceptibility signals comparing SWI and CE-SWI characteristics. The relationship between these susceptibility signals and CE-T1w tumour volume was analysed by using Spearman's rank correlation coefficient and Kruskal-Wallis-test. Tumour biopsies of different susceptibility signals were performed in one patient.
Comparison of SWI and CE-SWI demonstrated different susceptibility signals. Susceptibility signals visible on SWI images are consistent with ITSS; those only seen on CE-SWI were identified as CIPS. Correlation with CE-T1w tumour volume revealed that CIPS were especially present in small or medium-sized GBM (Spearman's rho r = 0.843, P < 0.001). Histology identified the area with CIPS as the tumour invasion zone, while the area with ITSS represented micro-haemorrhage, highly pathological vessels and necrosis.
CE-SWI adds information to the evaluation of GBM before therapy. It might have the potential to non-invasively identify the tumour invasion zone as demonstrated by biopsies in one case.
• MRI is used to help differentiate between low- and high-grade gliomas. • Contrast-enhanced susceptibility-weighted MRI (CE-SWI) helps to identify patients with glioblastoma multiforme. • CE-SWI delineates the susceptibility signal (CIPS and ITSS) more than the native SWI. • CE-SWI might have the potential to non-invasively identify the tumour invasion zone.
SWI 可帮助识别高级别胶质瘤（HGG）。本研究的目的是分析 SWI 和 CE-SWI 的特征，即对比剂诱导的相位偏移（CIPS）与肿瘤内磁化率信号（ITSS）之间的关系及其与多形性胶质母细胞瘤（GBM）肿瘤体积的关系。
对 29 例患者进行 MRI 研究，以评估 SWI 和 CE-SWI 特征的不同磁化率信号。通过 Spearman 秩相关系数和 Kruskal-Wallis 检验分析这些磁化率信号与 CE-T1w 肿瘤体积之间的关系。对一位患者的不同磁化率信号进行肿瘤活检。
SWI 和 CE-SWI 的比较显示出不同的磁化率信号。SWI 图像上可见的磁化率信号与 ITSS 一致；仅在 CE-SWI 上可见的磁化率信号被确定为 CIPS。与 CE-T1w 肿瘤体积的相关性表明，CIPS 尤其存在于小或中等大小的 GBM 中（Spearman 的 rho r=0.843，P<0.001）。组织学将 CIPS 所在区域鉴定为肿瘤侵袭区，而 ITSS 所在区域代表微出血、高度病理性血管和坏死。
CE-SWI 在治疗前对 GBM 的评估提供了更多信息。在一个病例中，通过活检证明，它具有潜在能力以非侵入性方式识别肿瘤侵袭区。
MRI 用于帮助区分低级别和高级别胶质瘤。
对比增强磁化率加权 MRI（CE-SWI）有助于识别多形性胶质母细胞瘤患者。
CE-SWI 比原始 SWI 更能描绘磁化率信号（CIPS 和 ITSS）。
CE-SWI 可能具有潜在能力以非侵入性方式识别肿瘤侵袭区。
