Institute of Diagnostic and Interventional Neuroradiology, University Bern, Inselspital, Freiburgstrasse 4, 3010 Bern, Switzerland.
Eur J Radiol. 2012 Feb;81(2):272-6. doi: 10.1016/j.ejrad.2010.12.021. Epub 2011 Jan 7.
Susceptibility-weighted MR imaging (SWI) is usually obtained without administration of intravenous gadolinium (Gd). However, it is occasionally necessary to perform SWI after Gd is injected. The effects of Gd on SWI have not been systematically examined. The aim of this prospective study was to investigate whether performing SWI after Gd would influence the diagnostic image quality, parenchymal signal and vascular enhancement. An additional aim is to suggest potential future applications for Gd-enhanced SWI.
SWI was performed in 31 subjects before and after Gd administration. 17 cases were examined in a 1.5T scanner and the remaining 14 were scanned at 3T. The pre- and post-Gd images were analysed for signal changes in the cerebral grey matter (GM), white matter (WM) as well as for enhancement in the superficial and deep venous system. The visibility of the veins was graded on subtraction maps.
The Gd-enhanced images showed no image quality degradation and no significant signal intensity change in the GM and WM as compared to the pre-Gd images (p>0.05). After Gd-administration significant enhancement of the venous sinuses was noticed (p<0.005), while the deep and cortical veins were poorly enhanced as confirmed by the calculated subtraction maps. The results showed no significant difference at variable MRI field strengths.
It is possible to perform SWI after Gd injection without information loss or signal change in the parenchyma. The most significant difference is the enhancement of the cerebral venous sinuses. Potential future applications are discussed.
磁敏感加权成像（SWI）通常无需静脉注射钆（Gd）即可获得。然而，偶尔需要在注射 Gd 后进行 SWI。尚未系统地检查 Gd 对 SWI 的影响。本前瞻性研究旨在调查在 Gd 注射后进行 SWI 是否会影响诊断图像质量、实质信号和血管增强。另一个目的是为 Gd 增强 SWI 提出潜在的未来应用。
在 Gd 给药前后对 31 例受试者进行了 SWI。17 例在 1.5T 扫描仪中进行检查，其余 14 例在 3T 扫描仪中进行检查。对脑灰质（GM）和白质（WM）的信号变化以及浅静脉和深静脉系统的增强进行了分析。对减影图上的静脉可见性进行了分级。
与 Gd 给药前的图像相比，Gd 增强图像没有图像质量下降，也没有 GM 和 WM 信号强度的显著变化（p>0.05）。给药后，静脉窦明显增强（p<0.005），而深静脉和皮质静脉的增强程度较差，通过计算减影图得到证实。结果在不同 MRI 场强下无显著差异。
在不丢失信息或实质信号变化的情况下，可以在 Gd 注射后进行 SWI。最显著的差异是脑静脉窦的增强。讨论了潜在的未来应用。
