格拉司琼用于控制脊髓麻醉下剖宫产术中恶心呕吐的随机安慰剂对照试验。
Randomized, placebo-controlled trial of granisetron for control of nausea and vomiting during cesarean delivery under spinal anesthesia.
作者信息
Dasgupta Mandira, Biswas B N, Chatterjee Suman, Mazumder Pinaki, Bhanja Chowdhury Manash
机构信息
Department of Obstetrics & Gynaecology, Calcutta Medical College, 88, College Street, Kolkata, 700 073 India ; 559, Block N, New Alipore, Kolkata, 700 053 India.
出版信息
J Obstet Gynaecol India. 2012 Aug;62(4):419-23. doi: 10.1007/s13224-012-0291-0. Epub 2012 Oct 16.
OBJECTIVES
The objective of this study was to evaluate the efficacy and safety of granisetron (5HT3 receptor antagonist) on the incidence of nausea and vomiting in cesarean deliveries under spinal anesthesia.
METHODS
In the randomized, double-blind study, 80 parturients received granisetron 40 μg/kg or placebo (n = 40 each) intravenously, immediately after clamping of the fetal umbilical cord. Nausea, vomiting, and adverse events were then observed for 24 h after administration of spinal anesthesia.
RESULTS
A complete response (defined as no postoperative nausea and vomiting) during 0-4 h after administration of spinal anesthesia was achieved in 80 % of patients with granisetron and in 45 % of patients with placebo. The corresponding incidences during (4-24 h) were 82.5 and 55 % (P value <0.05). No difference in adverse events was observed in any of the groups.
CONCLUSIONS
Prophylactic use of granisetron is effective for preventing emetic episodes during spinal anesthesia for cesarean delivery.
目的
本研究旨在评估格拉司琼（5-羟色胺3受体拮抗剂）对脊髓麻醉下剖宫产术中恶心呕吐发生率的疗效和安全性。
方法
在这项随机双盲研究中，80名产妇在胎儿脐带结扎后立即静脉注射40μg/kg格拉司琼或安慰剂（每组各40名）。然后在脊髓麻醉给药后24小时观察恶心、呕吐及不良事件。
结果
脊髓麻醉给药后0至4小时内，80%接受格拉司琼治疗的患者和45%接受安慰剂治疗的患者获得了完全缓解（定义为术后无恶心呕吐）。（4至24小时）相应的发生率分别为82.5%和55%（P值<0.05）。各组在不良事件方面未观察到差异。
结论
预防性使用格拉司琼对预防剖宫产脊髓麻醉期间的呕吐发作有效。
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