Yang Shuai, Zhu Wen-Fei, Shu Yue-Long
World Health Organization Global Influenza Collaboration Centre for Reference and Research State Key Laboratory for Molecular Virology and Genetic Engineering, Chinese Center for Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, Beijing 102206, China.
Bing Du Xue Bao. 2013 May;29(3):330-6.
Swine influenza viruses (SIVs) are respiratory pathogens of pigs. They cause both economic bur den in livestock-dependent industries and serious global public health concerns in humans. Because of their dual susceptibility to human and avian influenza viruses, pigs are recognized as intermediate hosts for genetic reassortment and interspecies transmission. Subtypes H1N1, H1N2, and H3N2 circulate in swine populations around the world, with varied origin and genetic characteristics among different continents and regions. In this review, the role of pigs in evolution of influenza A viruses, the genetic evolution of SIVs and interspecies transmission of SIVs are described. Considering the possibility that pigs might produce novel influenza viruses causing more outbreaks and pandemics, routine epidemiological surveillance of influenza viruses in pig populations is highly recommended.
猪流感病毒（SIVs）是猪的呼吸道病原体。它们既给依赖家畜的产业带来经济负担，也引发了严重的全球公共卫生问题。由于猪对人类和禽流感病毒具有双重易感性，因此猪被认为是基因重配和跨物种传播的中间宿主。H1N1、H1N2和H3N2亚型在世界各地的猪群中传播，不同大陆和地区的病毒起源和遗传特征各不相同。在这篇综述中，描述了猪在甲型流感病毒进化中的作用、SIVs的基因进化以及SIVs的跨物种传播。鉴于猪可能产生引发更多疫情和大流行的新型流感病毒，强烈建议对猪群中的流感病毒进行常规流行病学监测。
