Valle M J, Jordan G W, Haahr S, Merigan T C
J Immunol. 1975 Jul;115(1):230-3.
A factor with antiviral activity has been produced in vitro by combined macrophage-lymphocyte cultures from patients with recent herpes labialis in response to HSV antigen stimulation. It has been designated "immune interferon" and characterized in comparison to several other human interferons. It was shown to be relatively unstable at pH 2 and at 56 degrees C. Rabbit anti-human leukocyte interferon serum was shown to be less active against immune interferon than against diploid cell interferon or against vesicle fluid interferon. The possibility of immune interferon being a totally different anti-viral protein or a protein with certain shared antigen determinants or structures with classical viral interferon is discussed. A simplified method for the assay of anti-interferon sera with microtiter plates is also described.
近期患唇疱疹的患者的巨噬细胞 - 淋巴细胞联合培养物在体外经单纯疱疹病毒（HSV）抗原刺激后产生了一种具有抗病毒活性的因子。它被命名为“免疫干扰素”，并与其他几种人干扰素进行了特性比较。结果显示，它在pH 2和56摄氏度时相对不稳定。兔抗人白细胞干扰素血清对免疫干扰素的活性比对二倍体细胞干扰素或水疱液干扰素的活性低。文中讨论了免疫干扰素是一种完全不同的抗病毒蛋白，还是一种与经典病毒干扰素具有某些共同抗原决定簇或结构的蛋白的可能性。还描述了一种用微量滴定板检测抗干扰素血清的简化方法。
