Zhejiang Spine Research Center, Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, China.
Neurosurg Focus. 2013 Aug;35(2):E3. doi: 10.3171/2013.3.FOCUS12406.
This study aimed to investigate the incidence rate of heterotopic ossification (HO) after implantation of Coflex interspinous devices. Possible risk factors associated with HO were evaluated.
The authors retrospectively analyzed patients who had undergone single-level (L4-5) implantation of a Coflex device for the treatment of lumbar spinal stenosis. Patient data recorded were age, sex, height, weight, body mass index, smoking habits, and surgical time. Heterotopic ossification was identified through lumbar anteroposterior and lateral view radiographs. The authors developed a simple classification for defining HO and compared HO-positive and HO-negative cases to identify possible risk factors.
Among 32 patients with follow-up times of 24-57 months, HO was detectable in 26 (81.2%). Among these 26 patients, HO was in the lateral space of the spinous process but not in the interspinous space in 8, HO was in the interspinous space but did not bridge the adjacent spinous process in 16, and interspinous fusion occurred at the level of the device in 2. Occurrence of HO was not associated with patient age, sex, height, weight, body mass index, smoking habits, or surgical time.
A high incidence of HO has been detected after implantation of Coflex devices. Clinicians should be aware of this possible outcome, and more studies should be conducted to clarify the clinical effects of HO.
本研究旨在调查 Coflex 棘突间装置植入后异位骨化（HO）的发生率。评估与 HO 相关的可能危险因素。
作者回顾性分析了接受单节段（L4-5）Coflex 装置植入治疗腰椎管狭窄症的患者。记录的患者数据包括年龄、性别、身高、体重、体重指数、吸烟习惯和手术时间。通过腰椎前后位和侧位 X 线片确定异位骨化。作者制定了一种简单的分类方法来定义 HO，并比较了 HO 阳性和 HO 阴性病例，以确定可能的危险因素。
在随访时间为 24-57 个月的 32 例患者中，26 例（81.2%）可检测到 HO。在这 26 例患者中，8 例 HO 位于棘突侧方但不在棘突间，16 例 HO 位于棘突间但不跨越相邻棘突，2 例在装置水平发生棘突间融合。HO 的发生与患者年龄、性别、身高、体重、体重指数、吸烟习惯或手术时间无关。
在 Coflex 装置植入后检测到 HO 的发生率较高。临床医生应意识到这种可能的结果，并应进行更多的研究以阐明 HO 的临床效果。
