一种涉及嗅觉受体基因选择的表观遗传陷阱。

An epigenetic trap involved in olfactory receptor gene choice.

机构信息

Fishberg Department of Neuroscience and Friedman Brain Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

出版信息

Dev Cell. 2013 Jul 29;26(2):120-1. doi: 10.1016/j.devcel.2013.07.011.

DOI:10.1016/j.devcel.2013.07.011

PMID:23906063

Abstract

Reporting recently in Cell, Lyons et al. (2013) reveal key roles for transient LSD1 histone demethylase activity in activation of a single olfactory receptor allele and suppression of the rest of the olfactory receptor gene family, thereby locking in the expression of a single olfactory receptor per sensory neuron.

摘要

莱昂斯等人在最近的《细胞》杂志上报告称，瞬时 LSD1 组蛋白去甲基酶活性在激活单个嗅觉受体等位基因和抑制其余嗅觉受体基因家族方面发挥着关键作用，从而使每个感觉神经元只表达一个嗅觉受体。