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多发性硬化症治疗的个性化:使用螯合疗法。

Personalization of multiple sclerosis treatments: using the chelation therapy approach.

机构信息

Charity Association for Person-Centered Medicine, Bologna, Italy.

出版信息

Explore (NY). 2013 Jul-Aug;9(4):244-8. doi: 10.1016/j.explore.2013.04.003.

Abstract

Though Multiple Sclerosis (MS) sufferers are probably genetically predisposed, toxic metal poisoning (TMP) does seem an increasingly likely environmental trigger. The technique for measuring and clearing TMP was chelation therapy using ethylene-diamine-tetracetic acid (EDTA), which revealed aluminum accumulation in both cases. The first patient, initially benefiting from removing dental fillings that had leaked mercury, also showed gadolinium accumulation from scan contrast medium, and a genomic deficiency of glutathione transferase M1. Glutathione production was impaired and hence also liver detoxification functions. The personal protocol involved glutathione administration and deutrosulfazyme to enhance oxygenation and alleviate oxidative stress. As aluminum began to clear with EDTA infusion, the extracellular/intracellular water ratio was carefully monitored, and carbohydrates limited. In the second case, aluminum poisoning responded to EDTA chelation therapy with eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA), multivitamins, and glutathione administration, again followed by deutrosulfazyme, water ratio control, and dietary correction. The two personalized protocols presented here tend to confirm the hypothesis of TMP as an environmental or iatrogenic trigger for MS, especially when inadequate detoxification lies at the root. Cleansing by chelation therapy, properly understood, can be efficacious, especially bearing in mind the altered cellular water ratio.

摘要

尽管多发性硬化症 (MS) 患者可能具有遗传易感性,但有毒金属中毒 (TMP) 似乎确实是一种越来越可能的环境触发因素。用于测量和清除 TMP 的技术是螯合疗法,使用乙二胺四乙酸 (EDTA),这两种情况都显示出铝的积累。第一位患者最初从去除泄漏汞的牙填充物中受益,也显示出扫描对比剂中的钆积累,以及谷胱甘肽转移酶 M1 的基因组缺陷。谷胱甘肽的产生受损,因此肝脏解毒功能也受损。个人方案包括谷胱甘肽给药和二硫苏糖醇,以增强氧合作用并减轻氧化应激。随着 EDTA 输注清除铝,仔细监测细胞外/细胞内水比,并限制碳水化合物。在第二种情况下,铝中毒对 EDTA 螯合疗法、二十碳五烯酸 (EPA)/二十二碳六烯酸 (DHA)、多种维生素和谷胱甘肽给药有反应,再次使用二硫苏糖醇、水比控制和饮食纠正。这里提出的两种个性化方案倾向于证实 TMP 作为 MS 的环境或医源性触发因素的假设,尤其是在解毒不足是根本原因的情况下。螯合疗法的净化,如果正确理解,可以是有效的,特别是考虑到改变的细胞内水比。

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