MBI, Ohio State University, Columbus, OH 43210, USA.
Math Biosci Eng. 2013 Jun;10(3):609-24. doi: 10.3934/mbe.2013.10.609.
We consider a model incorporating the influence of innate and adaptive immune responses on malaria pathogenesis. By calculating the model reproduction number for a special representation of cytokine interaction, we have shown that the cytokine tumour necrosis factor-α can be administered to inhibit malaria infection. We have also found that if the cytokine F ∗ and a generic drug of efficacy ε are administered as dual therapy then clearance of the parasite can be achieved even for a generic drug of low efficacy. Our study is recommending administration of dual therapy as a strategy to prevent parasites from developing resistance to malaria treatment drugs.
我们考虑了一个将先天和适应性免疫反应的影响纳入疟疾发病机制的模型。通过计算细胞因子相互作用的特殊表示形式的模型繁殖数，我们表明细胞因子肿瘤坏死因子-α可以被给予以抑制疟疾感染。我们还发现，如果细胞因子 F ∗ 和一种通用药物的疗效 ε 作为双重治疗给予，则即使是疗效较低的通用药物，也可以清除寄生虫。我们的研究建议给予双重治疗作为一种策略，以防止寄生虫对疟疾治疗药物产生耐药性。
