Triki Sonia, Fekih Ons, Hellara Ilhem, Neffati Fadoua, Douki Wahiba, Hamda Khaldoun Ben, Maatouk Faouzi, Najjar Mohamed Fadhel
Department of biochemistry-toxicology, Fattouma Bourguiba university hospital, Monastir, Tunisia.
Ann Biol Clin (Paris). 2013 Jul-Aug;71(4):438-42. doi: 10.1684/abc.2013.0857.
Serum cystatin C concentration was recently reported as a marker of cardiovascular disease (CVD). In the present study, we evaluated the association between the increase of serum cystatin C levels and the risk of CVD in type 2 diabetes. 42 patients with type 2 diabetes were included in the present study; 27 of them have CVD. The control group consisted of 30 healthy adults. Cystatin C, creatinine, microalbuminuria and CRP were measured on Cobas 6000(TM). Cystatine C level was significantly higher in patients with CVD. A significant difference in serum cystatin C was found in patients with and without CVD among albuminuria. No difference in serum cystatin C levels was found according to number of affected vessels. A cystatin C level above 1.10 mg/L was associated with increase of risk of CVD with significant difference (OR = 42.52; IC 95% 1.455 to 1242.827 and p = 0.029). Our results suggested that the increase of serum cystatin C concentrations is a potential marker for CVD in diabetes.
血清胱抑素C浓度最近被报道为心血管疾病（CVD）的一个标志物。在本研究中，我们评估了2型糖尿病患者血清胱抑素C水平升高与CVD风险之间的关联。本研究纳入了42例2型糖尿病患者；其中27例患有CVD。对照组由30名健康成年人组成。使用Cobas 6000（TM）检测胱抑素C、肌酐、微量白蛋白尿和CRP。CVD患者的胱抑素C水平显著更高。在有蛋白尿和无蛋白尿的患者中，有CVD和无CVD患者的血清胱抑素C存在显著差异。根据受累血管数量，血清胱抑素C水平未发现差异。胱抑素C水平高于1.10 mg/L与CVD风险增加相关，差异有统计学意义（OR = 42.52；95%置信区间1.455至1242.827，p = 0.029）。我们的结果表明，血清胱抑素C浓度升高是糖尿病患者CVD的一个潜在标志物。
