Kouamou Edwige, Stépanian Alain, Khadra Fadi, de Prost Dominique, Teillet France
Service d'hématologie biologique et transfusion, AP-HP, Hôpital Louis Mourier, Colombes, France.
Ann Biol Clin (Paris). 2013 Jul-Aug;71(4):481-4. doi: 10.1684/abc.2013.0863.
A 58-year-old patient, without any notable medical history, except for alcoholism and treated hypertension, developed anemia and leukopenia with macrocytosis. Folate deficiency was diagnosed and subsequently treated. Despite folate supplementation, the hematological parameters did not normalize. Further diagnosis investigations were led to search for uncommon etiologies of anemia and leukoneutropenia. We diagnosed severe copper deficiency on the basis of decreased plasma levels of copper and ceruloplasmin. Copper supplementation improved blood counts within three months. This case illustrates hematological disorders due to copper deficiency, initially masked by an associated folate deficiency. The copper deficiency etiology was not identified in this case.
一名58岁患者，除酗酒和接受过高血压治疗外无其他显著病史，出现贫血、白细胞减少伴大细胞症。诊断为叶酸缺乏并随后进行了治疗。尽管补充了叶酸，但血液学参数并未恢复正常。进一步的诊断性检查旨在寻找贫血和白细胞减少症的罕见病因。我们根据血浆铜和铜蓝蛋白水平降低诊断为严重铜缺乏。补充铜后三个月内血细胞计数得到改善。该病例说明了由铜缺乏引起的血液系统疾病，最初被相关的叶酸缺乏所掩盖。本病例未确定铜缺乏的病因。
