Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
Adv Drug Deliv Rev. 2013 Dec;65(15):1933-50. doi: 10.1016/j.addr.2013.07.015. Epub 2013 Jul 29.
Biosensors are important tools in biomedical research. Moreover, they are becoming an essential part of modern healthcare. In the future, biosensor development will become even more crucial due to the demand for personalized-medicine, point-of care devices and cheaper diagnostic tools. Substantial advances in sensor technology are often fueled by the advent of new materials. Therefore, nanomaterials have motivated a large body of research and such materials have been implemented into biosensor devices. Among these new materials carbon nanotubes (CNTs) are especially promising building blocks for biosensors due to their unique electronic and optical properties. Carbon nanotubes are rolled-up cylinders of carbon monolayers (graphene). They can be chemically modified in such a way that biologically relevant molecules can be detected with high sensitivity and selectivity. In this review article we will discuss how carbon nanotubes can be used to create biosensors. We review the latest advancements of optical carbon nanotube based biosensors with a special focus on near-infrared (NIR)-fluorescence, Raman-scattering and fluorescence quenching.
生物传感器是生物医学研究中的重要工具。此外，它们正成为现代医疗保健的重要组成部分。由于对个性化医疗、即时护理设备和更廉价诊断工具的需求，未来生物传感器的发展将变得更加关键。传感器技术的重大进展通常得益于新材料的出现。因此，纳米材料激发了大量的研究，并且这些材料已经被应用于生物传感器设备中。在这些新材料中，由于其独特的电子和光学特性，碳纳米管（CNT）是生物传感器特别有前途的构建块。碳纳米管是单层碳原子（石墨烯）卷起的圆柱体。它们可以进行化学修饰，以便能够以高灵敏度和选择性检测生物相关分子。在这篇综述文章中，我们将讨论如何使用碳纳米管来创建生物传感器。我们回顾了基于碳纳米管的光学生物传感器的最新进展，特别关注近红外（NIR）荧光、拉曼散射和荧光猝灭。
