Cipolato Oscar, Fauconneau Matthias, LeValley Paige J, Nißler Robert, Suter Benjamin, Herrmann Inge K
Nanoparticle Systems Engineering Laboratory, Department of Mechanical and Process Engineering (D-MAVT), Institute of Energy and Process Engineering (IEPE), ETH Zurich, Zurich, Switzerland.
Particles Biology Interactions Laboratory, Department of Materials Meet Life, Swiss Federal Laboratories for Materials Science and Technology (Empa), St. Gallen, Switzerland.
J Biophotonics. 2025 Feb;18(2):e202400417. doi: 10.1002/jbio.202400417. Epub 2024 Dec 23.
Fluorescence-guided surgeries, including tumor resection and tissue soldering, are advancing the frontiers of surgical precision by offering enhanced control that minimizes tissue damage, improving recovery and outcomes. However, integrating fluorescence visualization with real-time temperature monitoring remains a challenge, limiting broader clinical use. We address this issue with an augmented reality (AR) visor that combines nanomaterial excitation, fluorescence detection, and temperature monitoring. Using advanced fluorescent nanoparticles like indocyanine green-doped particles and carbon nanotubes, the visor provides a comprehensive view of both the surgical field and sub-surface conditions invisible to the naked eye. This integration improves the safety and efficacy of fluorescence-guided surgeries, including laser tissue soldering, by ensuring optimal temperatures and laser guidance in real time. The presented technology enhances existing surgical techniques and supports the development of new strategies and sensing technologies in areas where traditional methods fall short, marking significant progress in precision surgery and potentially improving patient care.
荧光引导手术,包括肿瘤切除和组织焊接,通过提供增强的控制来推进手术精度的前沿,这种控制可将组织损伤降至最低,改善恢复情况和手术结果。然而,将荧光可视化与实时温度监测相结合仍然是一个挑战,限制了其更广泛的临床应用。我们通过一种增强现实(AR)面罩来解决这个问题,该面罩结合了纳米材料激发、荧光检测和温度监测。使用吲哚菁绿掺杂颗粒和碳纳米管等先进的荧光纳米颗粒,该面罩提供了肉眼不可见的手术区域和皮下状况的全面视图。这种整合通过实时确保最佳温度和激光引导,提高了包括激光组织焊接在内的荧光引导手术的安全性和有效性。所展示的技术增强了现有的手术技术,并支持在传统方法不足的领域开发新的策略和传感技术,标志着精确手术取得了重大进展,并有可能改善患者护理。