Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
J Neuroimmunol. 2013 Sep 15;262(1-2):85-91. doi: 10.1016/j.jneuroim.2013.05.007. Epub 2013 Jul 30.
The role of interleukin 17 (IL-17) to epilepsy-associated cortical tubers of tuberous sclerosis complex (TSC) is unknown. We investigated the expression patterns of the IL-17 and IL-17 receptor (IL-17R) in cortical tubers of TSC compared with normal control cortex (CTX). We found that IL-17 and IL-17R were clearly upregulated in cortical tubers at the protein levels. Immunostaining indicated that IL-17 was specifically distributed in the innate immunity cells (DNs, GCs, astrocytes, and microglia) and adaptive immunity cells (T-lymphocytes) as well as the endothelial cells of blood vessels. The overexpression and distribution patterns of IL-17 may be involved in the epileptogenicity of cortical tubers in TSC.
白细胞介素 17（IL-17）在结节性硬化症（TSC）相关皮质结节中致痫作用尚不清楚。我们研究了 IL-17 和 IL-17 受体（IL-17R）在 TSC 皮质结节中的表达模式，并与正常对照皮质（CTX）进行了比较。我们发现，IL-17 和 IL-17R 在蛋白水平上明显上调。免疫组化表明，IL-17 特异性分布于固有免疫细胞（DN、GC、星形胶质细胞和小胶质细胞）和适应性免疫细胞（T 淋巴细胞）以及血管内皮细胞。IL-17 的过度表达和分布模式可能与 TSC 皮质结节的致痫性有关。
