Nat Cell Biol. 2013 Aug;15(8):891-3. doi: 10.1038/ncb2810.
The transcription factor p73, a close relative of p53, has complex yet poorly understood roles in tumorigenesis. TAp73, a p73 variant, has now been shown to promote cancer cell proliferation by regulating glucose metabolism to control cellular biosynthetic pathways and antioxidant capacity.
转录因子 p73 是 p53 的近亲,在肿瘤发生中具有复杂但尚未被充分理解的作用。TAp73 是 p73 的一种变体,现已被证明通过调节葡萄糖代谢来控制细胞合成途径和抗氧化能力,从而促进癌细胞增殖。