Dwork A J, Lawler G, Zybert P A, Durkin M, Osman M, Willson N, Barkai A I
Department of Neuropathology and Neurotoxicology, New York State Psychiatric Institute, New York 10032.
Brain Res. 1990 Jun 4;518(1-2):31-9. doi: 10.1016/0006-8993(90)90950-g.
Rats aged 15, 28, or 42 days were injected intraperitoneally with iron-59 and were sacrificed at varying intervals. Total acquisition of iron-59 by the brain, when compared to levels of iron-59 in blood sampled 48 h after injection, diminished with increasing age at injection. Cerebral levels of iron-59 in animals injected at age 15 days did not change with postinjection interval despite rapidly decreasing serum levels of iron-59. Thus, iron acquired by the brain early in postnatal development becomes sequestered in that organ. However, autoradiography of the brains of animals injected at age 15 days showed definite changes over time in the anatomic distribution of the isotope. This suggests that mechanisms may exist for the translocation of iron from one area of the brain to another.
分别给15日龄、28日龄或42日龄的大鼠腹腔注射铁-59，并在不同时间间隔后处死。与注射后48小时采集的血液中铁-59水平相比，大脑对铁-59的总摄取量随着注射时年龄的增加而减少。尽管注射后血清中铁-59水平迅速下降，但15日龄时注射的动物大脑中铁-59水平并未随注射后时间间隔而变化。因此，出生后早期发育阶段大脑摄取的铁会被隔离在该器官中。然而，对15日龄时注射的动物大脑进行放射自显影显示，随着时间的推移，同位素的解剖分布有明显变化。这表明可能存在铁从大脑一个区域转移到另一个区域的机制。
