人胎脑中β-神经生长因子mRNA的检测

Detection of beta-nerve growth factor mRNA in the human fetal brain.

作者信息

Pizzuti A, Borsani G, Falini A, Rugarli E I, Sidoli A, Baralle F E, Scarlato G, Silani V

机构信息

Dino Ferrari Center, Institute of Neurology, University of Milan Medical School, Italy.

出版信息

Brain Res. 1990 Jun 4;518(1-2):337-41. doi: 10.1016/0006-8993(90)90994-m.

DOI:10.1016/0006-8993(90)90994-m

PMID:2390724

Abstract

Nerve growth factor (NGF) is a trophic molecule recently demonstrated to interact with different structures in the central nervous system. The expression of the beta-NGF mRNA from human fetal cortices at the 15-16th week of gestational age has been demonstrated and quantitated by polymerase chain reaction amplification of the specific cDNA. beta-NGF mRNA expression in the human brain coincides with the period of active differentiation and synaptogenesis, suggesting that the trophic agent plays a role in the cerebral development.

摘要

神经生长因子（NGF）是一种最近被证明可与中枢神经系统中不同结构相互作用的营养分子。通过对特定cDNA进行聚合酶链反应扩增，已证实并定量了孕15 - 16周人类胎儿皮质中β-NGF mRNA的表达。人类大脑中β-NGF mRNA的表达与活跃分化和突触形成期相吻合，这表明这种营养因子在大脑发育中发挥作用。