Department of Neurology, First Affiliated Hospital of China Medical University, Shenyang, 110001, China,
Biochem Genet. 2013 Dec;51(11-12):916-26. doi: 10.1007/s10528-013-9625-6. Epub 2013 Aug 2.
Previous studies have shown associations of fetuin-A (alpha2-Heremans-Schmid glycoprotein, AHSG) with various disorders, including insulin resistance, type 2 diabetes mellitus, metabolic syndrome, and atherosclerosis. In this study, genotype and allele frequencies of the rs4918 SNP in the AHSG gene were examined in 380 patients with ischemic stroke and 350 healthy controls from a Northern Han Chinese population via the PCR-RFLP technique. Frequencies of the GG genotype and the G allele in AHSG (rs4918) were significantly higher in patients with ischemic stroke or atherosclerotic cerebral infarction than those in the control group (P < 0.05). Logistic regression analysis demonstrated the significance of rs4918 in these patients, after adjustment for confounding factors (P < 0.05). These findings suggest that rs4918 SNPs of the AHSG gene are associated with a risk for ischemic stroke in a Northern Han Chinese population.
先前的研究表明，胎球蛋白-A（α2-赫尔曼斯-施密特糖蛋白，AHSG）与多种疾病有关，包括胰岛素抵抗、2 型糖尿病、代谢综合征和动脉粥样硬化。在这项研究中，通过 PCR-RFLP 技术，在 380 名缺血性脑卒中患者和 350 名来自北方汉族人群的健康对照中，检查了 AHSG 基因 rs4918 SNP 的基因型和等位基因频率。在缺血性脑卒中或动脉粥样硬化性脑梗死患者中，AHSG(rs4918)的 GG 基因型和 G 等位基因的频率明显高于对照组（P<0.05）。经过混杂因素调整后，逻辑回归分析显示 rs4918 在这些患者中有统计学意义（P<0.05）。这些发现表明，AHSG 基因的 rs4918 单核苷酸多态性与北方汉族人群缺血性脑卒中的风险相关。
