Institut de Pharmacologie Moléculaire et Cellulaire, Laboratory of Excellence 'Network for Innovation on Signal Transduction Pathways in Life Sciences', UMR7275, Centre National de la Recherche Scientifique, University of Nice-Sophia-Antipolis, 660 route des lucioles, 06560, Valbonne, France.
Neuromolecular Med. 2013 Dec;15(4):677-91. doi: 10.1007/s12017-013-8252-z. Epub 2013 Aug 2.
Small ubiquitin-like modifiers (SUMOs) are polypeptides resembling ubiquitin that are covalently attached to specific lysine residue of target proteins through a specific enzymatic pathway. Sumoylation is now seen as a key posttranslational modification involved in many biological processes, but little is known about how this highly dynamic protein modification is regulated in the brain. Disruption of the sumoylation enzymatic pathway during the embryonic development leads to lethality revealing a pivotal role for this protein modification during development. The main aim of this review is to briefly describe the SUMO pathway and give an overview of the sumoylation regulations occurring in brain development, neuronal morphology and synapse formation.
小泛素样修饰物 (SUMOs) 是一类类似于泛素的多肽，通过特定的酶促途径与靶蛋白的特定赖氨酸残基共价结合。现在，SUMO 化被视为参与许多生物过程的关键翻译后修饰，但对于这种高度动态的蛋白质修饰如何在大脑中调节知之甚少。在胚胎发育过程中破坏 SUMO 化酶途径会导致致死性，这表明这种蛋白质修饰在发育过程中起着关键作用。本篇综述的主要目的是简要描述 SUMO 途径，并概述脑发育、神经元形态和突触形成过程中发生的 SUMO 化调节。
