REQUIMTE, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, Porto, Portugal.
J Sep Sci. 2013 Oct;36(19):3220-5. doi: 10.1002/jssc.201300544. Epub 2013 Aug 28.
Over the last few years, there has been a growing concern about the presence of pharmaceuticals in the environment. The main objective of this study was to develop and validate an SPE method using surface response methodology for the determination of ibuprofen in different types of water samples. The influence of sample pH and sample volume on the ibuprofen recovery was studied. The effect of each studied independent variable is pronounced on the dependent variable (ibuprofen recovery). Good selectivity, extraction efficiency, and precision were achieved using 600 mL of sample volume with the pH adjusted to 2.2. LC with fluorescence detection was employed. The optimized method was applied to 20 water samples from the North and South of Portugal.
在过去的几年中，人们对环境中存在的药物越来越关注。本研究的主要目的是开发和验证一种使用表面响应方法的 SPE 方法，用于测定不同类型水样中的布洛芬。研究了样品 pH 值和样品体积对布洛芬回收率的影响。每个研究的独立变量对因变量（布洛芬回收率）的影响显著。使用 600 毫升样品体积和 pH 值调整为 2.2 的条件下，可获得良好的选择性、萃取效率和精密度。采用荧光检测的 LC 进行分析。优化后的方法应用于来自葡萄牙北部和南部的 20 个水样。
